Impact of contact lens wear on NLRP3 gene expression: Implications for ocular frailty in middle-aged adults
نویسندگان
چکیده
The inflammatory process plays a crucial role in frailty syndrome, which can appear middle age and is associated with poor health outcome. Consequently, gerontologists recommend screening biomarkers middle-aged adults to detect and, therefore, prevent chronic diseases mortality. External factors could be risk factor for because they generate extend the process. For these reasons, we analysed effect of long-term contact lens wear on mRNA level genes linked inflammation (IL-6, NLRP3, NK1R, CD73, MUC16 TRPV1 genes) conjunctival cells individuals, by quantitative PCR. Middle-aged wearers presented significant increase NLRP3 as well decrease CD73 level, comparison non-contact wearers. Additionally, checked potential correlation between transcript levels clinical changes participants’ ocular surface. Unlike molecular analysis, examination fails These data suggest that trigger an response orchestrated inflammasome modulated proteins. Further studies are needed confirm our gene expression findings at protein investigate CL onset frailty.
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2021
ISSN: ['1096-0007', '0014-4835']
DOI: https://doi.org/10.1016/j.exer.2020.108356